Decision domains
Name the decisions each founder can make independently, decisions requiring consultation, and decisions requiring unanimous approval.
Working cadence
Agree on weekly hours, core meetings, written updates, customer contact, location, response expectations, and how absences are communicated.
Money and expenses
Record current contributions, expense approval, salary expectations, financial runway, fundraising appetite, and when commitments will be reviewed.
Conflict and escalation
Define how disagreement is documented, when an external adviser is involved, and which behaviours are unacceptable even under pressure.
Confidentiality and work
Clarify confidential information, pre-existing work, ownership of trial outputs, third-party obligations, and records that must be maintained.
Pause or departure
Discuss what happens if commitment changes, a trial is stopped, someone accepts another role, or the founders decide not to continue.